Animal research: summaries


Knight A. Weighing the harms and benefits: invasive animal research. The Biochemist 2014; 36(3): 30-33.
Journal link (538 kb).

An invited article within a special edition of this Biochemical Society magazine entitled Replacement (of animals) in Research.



Knight A. 2010 laboratory animal statistics for Great Britain: implications for animal welfare. AATEX 2012; 17(2): 51-52.
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ABSTRACT
The 2010 laboratory animal use statistics for Great Britain revealed that just over 3.7 million scientific procedures using animals were commenced, representing an increase of 3% (105,000) over the previous year. Laboratory animal numbers have steadily risen across the preceding decade, largely due to increasing use of genetically altered animals. However, their use has disturbing implications for animal welfare. Similar concerns are raised by increasing use of non-human primates, and of procedures conducted without any form of anaesthesia.



Knight A. Weighing the costs and benefits of animal experiments. ALTEX Proc 2012; 1: 289-294.
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A paper from my presentation at the 8th World Congress on Alternatives & Animal Use in the Life Sciences, Montreal, 2011. Discusses the human benefits and animal impacts resulting from invasive animal research, the UK Bateson Review of Research Using Non-Human Primates, and also suggests policy reforms likely to result in a more accurate weighing of the human benefits and animal costs of invasive animal research.



Knight A. Welfare of laboratory animals under threat. Vet Practice [UK] 2010; 42(8): 8.
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The 2009 UK laboratory animal use figures were recently published by the Home Office. This articles analyses the animal welfare implications of these latest figures, and summarises the adverse welfare impacts of laboratory environments and protocols generally. It summarises the implications for laboratory animal welfare of the new European Directive governing laboratory animal use, and of UK budgetary cuts.



Knight A. Ethical duty to protect animals. Vet Times [UK] 2009; 39(34): 6, 8.
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Summarises systematic reviews demonstrating the poor human clinical and toxicological utility of animal models, their scientific limitations, and the bioethical considerations associated with invasive animal use, with an overview of rising laboratory animal numbers in the UK.


Knight A. Alternatives to animal testing. Vet Times [UK] 2009; 39(45): 8, 10.
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Describes factors increasing animal experimentation, and summarises non-animal research and testing methodologies, with pictures.


De Boo J & Knight A. Use of laboratory animals: revisiting reduction and refinement strategies. Vet Times [UK] 2010; 40(8): 6, 8-9.
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Summarises strategies for achieving reduction and refinement of laboratory animal use.



Knight A. No animals were harmed in the writing of this article. Irish Vet J 2009; 62(10): 648-650.
Download (146 kb). Referenced version (115 kb).

Similar to article 'Ethical duty to protect animals' above, with an overview of rising laboratory animal numbers in Ireland.



Knight A. Has laboratory animal welfare improved? Vet Practice 2009; 41(9): 49.
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Summarises systematic reviews demonstrating the poor human clinical and toxicological utility of animal models, and non-animal ('replacement') alternatives.