A letter in NAM Journal responding to a critique by Peter Groenen of our recent study showing very poor utility of animal experiments during preclinical drug testing.
Filipova D. Fox L. Gossman M. Herrmann K. Knight A. et al. (2026). Six decades of evidence: biological factors predominate among reported reasons for clinical drug failure: A response to “Persistent clinical attrition does not establish animal models as a root cause of drug-development failures” by Peter MA Groenen. NAM Journal 2(100136).doi.org/10.1016/j.namjnl.2026.100136.